AVNRT, AVRT (WPW syndrome) and other conditions involving an accessory pathway. Cardioversion of atrial fibrillation in patients without structural heart disease (reduced left ventricular function is considered a structural heart disease). Prophylaxis and treatment of symptomatic paroxysmal supraventricular tachyarrhythmia in patients without evidence of structural heart disease. Propafenone is usually not the first-line therapy in this patient category. Propafenone is usually not the first-line therapy in this patient category. Prophylaxis and treatment of life-threatening ventricular tachyarrhythmias. Propafenone and flecainide are both class I antiarrhythmic drugs and share several characteristics. Structural heart disease also increases the risk of developing arrhythmias during disopyramide treatment. Hypokalemia is likely to predispose to the pro-arrhythmic effects of disopyramide. Particularly, the degree of AV block may increase.ĭisopyramide may provoke or aggravate any ventricular arrhythmia, such as ventricular tachycardia, ventricular fibrillation, torsade de pointes etc). Preexisting AV block, bundle branch block or fascicular block may become worse. SA node function may become worse in patients with established SA node disease ( sinus node dysfunction, sick sinus syndrome)ĪV system (AV node, His bundle, Purkinje system) Prophylaxis and treatment of atrial fibrillation.Įffects of disopyramide on ECG, heart rhythm and conduction Effect on sinoatrial (SA) node. 
Prophylaxis and treatment of symptomatic ventricular tachyarrhythmias.Antiarrhythmic drugs Disopyramide Indications This is because these patients are at particularly high risk of developing life-threatening arrhythmias. Below follows a rather detailed declaration of ECG changes, arrhythmias and conduction defects that occur due to antiarrhythmic drugs, beta blockers and calcium channel blockers (inhibitors). The reader will notice that most of these drugs are contraindicated in patients with structural heart disease, as well as patients with reduced left ventricular function.
ECG changes and arrhythmias caused by digoxin were discussed previously. The effect of antiarrhythmic drugs, beta-blockers and calcium channel blockers on rhythm, conduction and ECG waveformsĪlthough the purpose of antiarrhythmic drugs is to control arrhythmias, these medications may also cause arrhythmias and confusing ECG changes.
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